Prediabetes increases the risk of pancreatic cancer: A meta-analysis of longitudinal observational studies

Xuefang Huang, Huan Li, Lisha Zhao, Lingli Xu and Hui Long

PLOS ONE, 2024, vol. 19, issue 10, 1-16

Abstract: Background: Glycemic disorder is closely related to the risk of pancreatic cancer, but previous studies focused on the influence of diabetes. The aim of this meta-analysis was to investigate the influence of prediabetes, an intermediate state between normoglycemia and diabetes, on the risk of pancreatic cancer. Methods: Relevant longitudinal observational studies were identified through a search of Medline, Embase, and Web of Science databases. To minimize the influence of between-study heterogeneity, a randomized-effects model was used to pool the results. Results: Nine cohort studies including 26,444,624 subjects were available for the meta-analysis. Among them, 2,052,986 (7.8%) had prediabetes at baseline, and the participants were followed for a mean duration of 5.9 years. It was found that, compared to people with normoglycemia, those with prediabetes had a higher incidence of pancreatic cancer (risk ratio [RR]: 1.42, 95% confidence interval: 1.36 to 1.49, p 0.05). Conclusions: Prediabetes may be associated with an increased risk of pancreatic cancer compared to normoglycemia.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0311911

DOI: 10.1371/journal.pone.0311911

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