Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis

Nader Muthanna, Xiaoyue Guan, Fouad Alzahrani, Badr Sultan Saif, Abdelrahman Seyam, Ahmed Alsalman, Ahmed Es Alajami and Ang Li

PLOS ONE, 2025, vol. 20, issue 1, 1-19

Abstract: Introduction: Different Guided Tissue Regeneration (GTR) procedures, such as membranes, bone substitute materials, and Autologous Platelet Concentrates (APCs), have been applied after surgical root canal treatment (SRCT), which produce different outcomes. This study aimed to evaluate the impact of regenerative procedures on the healing process following SRCT. Methods: A comprehensive search of PubMed, Embase, Scopus, Cochrane, and the Web of Science found Randomized Controlled Trials (RCTs) published until February 25, 2024. Manual searches were also conducted. Our main outcome was SRCT success or failure after GTR procedures. The Risk Ratio (RR) and failure rate meta-analysis used a fixed effects model with a 95% confidence interval (CI). Subgroup analyses were conducted based on the use of different GTR procedures for varying lesion types in SRCT. Results: Out of 1,605 records, 16 studies with 690 lesions were included. Overall, GTR procedures significantly improved healing after SRCT in both 2D (RR: 0.50; 95% CI, 0.34–0.73; P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0312751

DOI: 10.1371/journal.pone.0312751

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