Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study

Elyar Alizadeh Najmi, Zahra Mirzaasgari, Mohammad Reza Motamed and Armin Aslani

PLOS ONE, 2024, vol. 19, issue 11, 1-16

Abstract: Background: Multiple sclerosis (MS) is characterized by inflammation and demyelination in the central nervous system. Recent studies have suggested a potential association between MS and an increased risk of atherosclerosis, a systemic vascular disease involving arterial wall thickening. Understanding this relationship is crucial, given the heightened cardiovascular risk observed in MS patients. Objective: To investigate factors influencing the development of atherosclerosis in patients with multiple sclerosis (pwMS), focusing on carotid intima-media thickness (CIMT) as a marker. Methods: 114 pwMS (82 females and 32 males) and 127 control subjects (57 females and 70 males) were included. The mean CIMT between the two groups was compared. Additionally, the effects of annual relapse rate, EDSS (Expanded Disability Status Scale), MS duration, treatment duration, and type of Disease-modifying treatment (DMT) on CIMT were evaluated. Results: This study included 241 participants with a mean (SD) age of 41.13 years (10.93). CIMT was significantly higher in pwMS compared to controls (p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0314031

DOI: 10.1371/journal.pone.0314031

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