The development of preterm infants from low socio-economic status families: The combined effects of melatonin, autonomic nervous system maturation and psychosocial factors (ProMote): A study protocol

Theano Kokkinaki, Nicole Anagnostatou, Maria Markodimitraki, Theano Roumeliotaki, Manolis Tzatzarakis, Elena Vakonaki, Giorgos Giannakakis, Aristidis Tsatsakis and Eleftheria Hatzidaki

PLOS ONE, 2025, vol. 20, issue 1, 1-23

Abstract: Preterm births constitute a major public health issue and a chronic, cross-generational condition globally. Psychological and biological factors interact in a way that women from low socio-economic status (SES) are disproportionally affected by preterm delivery and at increased risk for the development of perinatal mental health problems. Low SES constitutes one of the most evident contributors to poor neurodevelopment of preterm infants. Maternal perinatal mental health disorders have persistent effects on behavioral and physiological functioning throughout the lifespan and may even be evident across generations. The overall objective of the proposed longitudinal, multi-disciplinary and multi-method study is to compare the association of psychosocial (maternal mental health, intersubjectivity, attachment, family functioning, dyadic coping and perceived social support), and biological factors (melatonin and heart rate variability) with preterm infants’ development at 9 months (corrected age), between low and high SES families. We will collect data from preterm neonates (

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0316520

DOI: 10.1371/journal.pone.0316520

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