The link between the atherogenic index of plasma and the risk of hypertension: Analysis from NHANES 2017–2020

Kaiyou Liu, Qingwei Ji, Shaoming Qin, Ling Liu, Hongwei Zhang, Huating Huang, Guihua Li and Junjun Chen

PLOS ONE, 2025, vol. 20, issue 1, 1-12

Abstract: Background: The atherogenic index of plasma (AIP) is a newly identified metabolic marker for atherosclerosis. However, there are inconsistent conclusions regarding the relationship between AIP and hypertension. Methods: The study subjects were sourced from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020. Logistic regression analyses were employed to explore the correlation between AIP and hypertension. The value of AIP in predicting hypertension was assessed using ROC curves, and their nonlinear relationship was described using restricted cubic splines (RCS). Subgroup analyses, interactions, and sensitivity analyses were also conducted. Results: The study included 7,067 participants who were sourced from the NHANES database. There were 2723 participants diagnosed hypertension. We observed a notable correlation between AIP and hypertension (OR:1.89, 95%CI: 1.11–3.22, P = 0.019). ROC curve showed AIP had a good predictive value for the onset of hypertension, with the AUC of 0.652 (95% CI:0.639–0.664, p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0317116

DOI: 10.1371/journal.pone.0317116

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