Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis

Young Ho Lee and Gwan Gyu Song

PLOS ONE, 2025, vol. 20, issue 1, 1-13

Abstract: Objectives: This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association between polymorphisms in the RANKL gene and susceptibility to RA. Method: We searched the Medline, Embase, and Cochrane databases for relevant publications up to September 2024. A meta-analysis was conducted to assess serum/plasma RANKL levels in patients with RA and controls, and to explore the relationship between RANKL rs9533156 and rs2277438 polymorphisms and RA susceptibility. Results: Ten studies encompassing 1,682 RA patients and 1,288 controls were analyzed. RANKL levels were significantly higher in RA patients compared to controls (SMD = 0.665, 95% CI = 0.290–1.040, P = 0.001). Subgroup analysis affirmed these findings’ consistency across different sample sizes and publication years. RANKL levels were positively associated with rheumatoid factor (RF) and Disease Activity Score-28 (DAS28) (RF correlation coefficient = 0.157, 95% CI = 0.028–0.282, P = 0.018; DAS28 correlation coefficient = 0.151, 95% CI = 0.125–0.370, P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0317517

DOI: 10.1371/journal.pone.0317517

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