Efficacy of different routes of triamcinolone acetonide administration on macular edema: A systematic review and network meta-analysis

Kexin Liu, Jinyang Yi, Juan Xu, Li Zhong and Na Su

PLOS ONE, 2025, vol. 20, issue 1, 1-20

Abstract: There is different administration routes of triamcinolone acetonide (TA) administration for macular edema, but the efficacy ranking remains unclear. The purpose of this study is to assess the efficacy of different administration routes of TA employed in macular edema. PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials were systematically searched for published articles comparing macular edema in patients with triamcinolone acetonide in different administration. The sparse network was evaluated using a random-effects model and consistency model within the Bayesian framework, utilizing the multinma package in R. The evidence was assessed based on the Grading of Recommendations. Assessment, Development, and Evaluation (GRADE) criteria. A total of 1138 citations were identified by our search, of which 20 RCTs enrolled 892 eyes. The network showed that intravitreal triamcinolone acetonide (IVTA) was associated with a statistically significant better best corrected visual acuity (BCVA) at the 12th week compared to placebo (MD: − 0.15, 95% CI: − 0.30 to − 0.01, P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0317782

DOI: 10.1371/journal.pone.0317782

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