Global prevalence of elevated estimated pulmonary artery systolic pressure in clinically stable children and adults with sickle cell disease: A systematic review and meta-analysis

Mobin Ghazaiean, Hadi Darvishi-Khezri, Behnam Najafi, Hossein Karami and Mehrnoush Kosaryan

PLOS ONE, 2025, vol. 20, issue 2, 1-31

Abstract: Background: The current study sought to determine the prevalence of elevated estimated pulmonary artery systolic pressure (ePASP) in clinically stable children and adults with sickle cell disease)SCD(worldwide. Methods: The studies included were identified through a search of databases such as PubMed, Scopus, Science Direct, Web of Science, and Embase, as well as Google Scholar engine, adhering to specific inclusion and exclusion criteria. Heterogeneity among the primary study results was assessed using the I-squared index, while publication bias was evaluated through funnel plots, Egger’s test, and trim and fill analysis. All statistical analyses were conducted using R software, version 4.3.0. Results: 79 primary studies were included, comprising 6,256 children (

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0318751 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 18751&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0318751

DOI: 10.1371/journal.pone.0318751

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().