Plasma-lyte solution versus saline in kidney transplantation: A systematic review and meta-analysis of randomized controlled trials

Yucai Chang, Yuechen Qin, Yue Zou, Haijian Zeng, Chunlan Li, Mengtian Qin, Jianyu Wu and Jian Ban

PLOS ONE, 2025, vol. 20, issue 4, 1-15

Abstract: Introduction: The optimal intravenous fluid for kidney transplantation (KT) is still controversial. This meta-analysis aimed to compare the efficacy and safety of plasma-lyte solution (PL) versus saline (NS) in kidney transplantation. Materials and methods: A comprehensive search was conducted across four databases (PubMed, Embase, Web of Science, and the Cochrane Library) to identify relevant randomized controlled trials (RCTs) comparing plasma-lyte and saline in kidney transplantation. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Meta-analyses of delayed graft function (DGF), creatinine levels, urine output, blood pH, bicarbonate, base excess, electrolytes, serum chloride, potassium and sodium immediately post-surgery were performed. Results: Totally six randomized controlled studies with 1197 patients were included. In comparison to the NS group, the PL group exhibited a significantly lower incidence of DGF (OR: 0.66, 95% CI: 0.51 to 0.86, P = 0.002) and reduced serum chloride (MD: -8.87, 95% CI: -13.50 to -4.25, P = 0.0002) as well as serum sodium(MD: -1.08, 95% CI: -1.54 to -0.61, P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0320082

DOI: 10.1371/journal.pone.0320082

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