Cross-cultural adaptation and psychometric evaluation of the urdu version of the morisky, greene, and levine medication adherence scale (MGLS-4) for major depressive disorder patients

Sohail Riaz, Fazli Khuda, Nadia Shamshad Malik, Nitasha Gohar, Ayesha Rashid, Abuzar Khan, Abdur Rahman, Sajid Ali, Asif Jan and Aqeel Nasim

PLOS ONE, 2025, vol. 20, issue 4, 1-15

Abstract: In Pakistan, Major depressive disorder (MDD) contributes significantly to the mental health burden. It is crucial to understand patients’ medication adherence status for developing a strategy for improving adherence and treatment outcomes. Therefore, a valid and reliable tool in the local Urdu language is required. The Morisky, Greene, and Levine Medication Adherence Scale (MGLS-4) is a reliable, valid and straightforward instrument to assess medication-taking behavior. The valid and reliable Urdu translation of MGLS-4 can fill this gap within the local context. Therefore, the present study aims to validate the Urdu Morisky, Green and Levine Adherence Scale (UMGLS-4) for MDD patients. This was a quantitative, cross-sectional validation study for Pakistani MDD patients. Reliability was measured using Cronbach’s α and for test-retest reliability intraclass correlation coefficient (ICC) was calculated. Validity was assessed through face validity, content validity, construct validity, and convergent validity with the Drug Attitude Inventory (DAI-10). Descriptive and inferential statistical analyses were carried out to demonstrate adherence level and statistical significance, respectively. Linear regression was applied to find the association between the UGMLS-4 score and demographic characteristics. The UMGLS-4 demonstrated high reliability (Cronbach’s α = 0.829) and a significant strong ICC (x = 0.601, p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0320258

DOI: 10.1371/journal.pone.0320258

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