The impact of brominated flame retardants exposure on serum total bilirubin: A cross-sectional analysis

Shanshan Huang, Tong Lin, Jialu Chen, Fen Zhou, Junjie Yang, Haiyan Mao and Zhouxin Yang

PLOS ONE, 2025, vol. 20, issue 3, 1-14

Abstract: Background: Brominated flame retardants (BFRs) are harmful, bioaccumulative, and persistent environmental pollutants, posing significant health risks. Elevated bilirubin levels can cause neurotoxicity and damage to the heart, liver, kidneys, and other organs. This study utilizes National Health and Nutrition Examination Survey (NHANES) data to investigate the association between exposure to BFRs and total bilirubin (TB) levels in adult participants. Methods: Based on data from the NHANES 2007-2016, TB levels were divided into tertiles. Spearman’s rank correlation was used to analyze the relationship between individual BFRs and TB levels. Weighted linear regression analysis, restricted cubic splines (RCS), and stratified analysis were conducted to assess the correlation between individual BFRs and TB levels. Weighted quantile sum (WQS) regression and quantile-based g-computation (QGC) analysis were used to comprehensively evaluate the impact of BFRs exposure on serum TB levels. Results: The study included 5831 participants. The results showed that PBB153, PBDE17, PBDE47, PBDE85, PBDE99, PBDE100, PBDE209, and PBDE183 were significantly correlated with TB levels (p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0320523

DOI: 10.1371/journal.pone.0320523

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