Effect of prone positioning in adult patients receiving veno-venous extracorporeal membrane oxygenation: A meta-analysis

Dehua Zeng, Aiqun Zhu and Jiayi Zhao

PLOS ONE, 2025, vol. 20, issue 3, 1-15

Abstract: Objective: To investigate the effects of prone positioning during extracorporeal membrane oxygenation (ECMO) and its effects on short-term and long-term survival. Methods: A computerized search was performed for all studies in PubMed, Web of Science, Embase, and the Cochrane Library up to December 31, 2023, including prospective and retrospective clinical studies of ECMO-treated patients with or without prone positioning. Titles, abstracts, and full-text articles were screened in duplicate by two investigators. The primary outcome was short‐term survival (survival at discharge or 1-month survival). The secondary outcomes included long-term survival (60-day survival, 90-day survival), ECMO duration, length of intensive care unit (ICU) stay and ECMO weaning. Results: Fifteen studies with 2608 patients were included, most of which were retrospective. The effect of prone versus non-prone positioning in ECMO patients was OR = 1.32; 95% CI, 0.88–1.97; P = 0.18 for short-term survival from the original data. The effects of prone positioning during ECMO were a significant increase in 28-day survival (OR = 2.54; 95% CI 1.71–3.76; P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0320532

DOI: 10.1371/journal.pone.0320532

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