Emerging trends and disparities in cardiovascular, kidney, and diabetes-related mortality: A retrospective analysis of the wide-ranging online data for epidemiologic research database

Aman Goyal, Humza Saeed, Samia Aziz Sulaiman, Wania Sultan, Momina Riaz Siddiqui, Mah I Kan Changez, Arman Qamar, Sarju Ganatra and Sourbha S Dani

PLOS ONE, 2025, vol. 20, issue 5, 1-16

Abstract: Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome, driven by metabolic risk factors like obesity, type 2 diabetes (DM-2), chronic kidney disease (CKD), and cardiovascular disease (CVD), leads to poorer health outcomes. Despite its rising prevalence and promising new therapies, trends and demographic disparities in CKM-related mortality among adults in the United States remain underexplored. Methodology: The study examined CDC WONDER death certificates for individuals aged 25+ who died from 1999 to 2022, with CVD as the main cause, while CKD and DM-2 as contributing factors. Age-adjusted mortality rates (AAMRs) and annual percent change (APC) were calculated by year, sex, age, race/ethnicity, region, and urbanization status. Results: From 1999 to 2022, 25,980 CKM-related deaths were recorded, with the AAMR decreasing from 5.3 to 0.4 per 1,000,000 population. AAMR rose significantly from 1999 to 2012 (APC: 7.03; p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0320670

DOI: 10.1371/journal.pone.0320670

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