Oxygen desaturation and lung ultrasonography as markers of diffuse parenchymal lung diseases severity

Ahmed Sadaka, Asmaa Gomaa, Hoda Abdelgawad, Nashwa H Abdelwahab, Eman Ahmed Hatata and Hanaa Shafiek

PLOS ONE, 2025, vol. 20, issue 5, 1-14

Abstract: Purpose: we aimed to evaluate lung ultrasound (LUS) and oxygen desaturation as markers for the severity of diffuse parenchymal lung disease (DPLD), specifically the fibrotic subtypes, and correlate the findings with high-resolution computed tomography (HRCT) and other physiologic parameters. Methods: A case-control study was conducted recruiting 31 DPLD patients and 20 age-matched healthy controls from our institution. All participants had a spirometry, HRCT, 6-minute walk test (6MWT), echocardiography and full-night cardio-respiratory polygraph. LUS for B-line quantification and pleural examination was performed on 6 zones bilaterally. Results: Compared to controls, patients had a statistically significant higher total number of B-lines, lower 6MWT nadir O2 and lower nadir nocturnal oxygen saturation (SpO2). Among patients; fibrotic DPLD (58.1%) had more B-lines, pleural irregularities with or without fragmentation, higher Warrick scores and lower 6MWT nadir SpO2 (p = 0.01, 0.008,

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0322657

DOI: 10.1371/journal.pone.0322657

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