Exploring the causal link between serum 25-hydroxyvitamin D concentrations and idiopathic sudden sensorineural hearing loss: Insights gained from a Mendelian randomization study involving two independent samples

Ying Zhao, Cong Yu, Hengchang Sun, Fangmei Xie, Jian Shen, Xiaoming Li, Xiaoyu Song, Wenfeng Luo, Jinhua He and Zeping Han

PLOS ONE, 2025, vol. 20, issue 5, 1-14

Abstract: Idiopathic sudden sensorineural hearing loss (ISSNHL) is defined by the rapid onset of hearing impairment without an identifiable etiology. The decreased serum concentrations of 25-hydroxyvitamin D(25(OH)D) was shown to be associated with decreased hearing ability. However, current cross-sectional studies have only demonstrated an association, failing to establish a causal link. Therefore, a comprehensive investigation is necessary to clarify the causal relationship between them. Analysis was done by using largescale genome-wide association analysis(GWAS) summary datasets to give information about the incidence of ISSNHL and genetically predicted serum 25(OH)D levels by a two-sample Mendelian randomization (MR) analysis. Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0322898

DOI: 10.1371/journal.pone.0322898

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