Feeding infant formula with low sn-2 palmitate causes changes in newborn’s intestinal environments through an increase in fecal soaped palmitic acid

Atsushi Ito, Hiromichi Shoji, Hiroko Arai, Satsuki Kakiuchi, Keigo Sato, Shinji Jinno, Naoto Takahashi, Kenichi Masumoto, Hitoshi Yoda and Toshiaki Shimizu

PLOS ONE, 2025, vol. 20, issue 5, 1-12

Abstract: Background/Objectives: Soaped palmitic acid (PA) has been reported to be excreted in stool after feeding infant formulas containing low sn-2 palmitate levels, which corresponds to high sn-1 or -3 palmitate levels. While an in vitro study showed that soaped PA inhibits the Bifidobacteria growth, few clinical studies have evaluated effects of soaped PA on intestinal environments of infants. In this study, we aimed to evaluate associations between increased fecal soaped PA levels and inhibition of growth of the intestinal microbiome using clinical data, and to evaluate changes in the intestinal environment with formula-feeding. Methods: This study was conducted as a secondary analysis to our observational study of Japanese 1-month-old infants (n = 172). Infant formulas were classified into high sn-2 formula (≥ 50%) and low sn-2 formula (

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0324256

DOI: 10.1371/journal.pone.0324256

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