Clinicopathological comparison of eccrine poroma and porocarcinoma: Ki-67 index is not a decisive factor

Anna-Stiina Meriläinen, Harri Sihto, Jorma Isola and Virve Koljonen

PLOS ONE, 2025, vol. 20, issue 5, 1-9

Abstract: Background: Eccrine poroma (EP) and porocarcinoma (EPC) arise from the intraepidermal part of the sweat gland. Clinically they resemble each other and cannot be distinguished without histopathological examination. EPC has been described as aggressive; however, the Ki-67 index is scarcely reported. The aim of this study was to compare clinicopathological factors between EP and EPC with special interest in Ki-67 index. Methods and Findings: 50 EP and 22 EPC samples with clinical data from 48 EP and 21 EPC patients were collected from the Finnish Biobanks. We performed immunohistochemistry using a Ki-67 antibody on a tissue microarray and analysed the Ki-67 index with ImmunoRatio 2.5-program. We analysed 48 EP and 21 EPC samples. EPC patients were older (p = 0.019) and their tumours larger (p = 0.003) but other than these there were no statistically significant differences. Ki-67 ratios were similar (medians: EP 0.6% and EPC 0.5%). The median follow-up time in EP group was 12 (range 1.5–30.6 years) and in EPC group 7 years (range 0.75–20.3 years). The survival of EP patients was better than EPC patients but did not reach statistical significance and, in the Cox multivariate analysis only age had statistically significant effect (HR 1.061, 95% CI 1.026–1.099, p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0324975

DOI: 10.1371/journal.pone.0324975

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