Mental health and health-related quality of life among adults with osteoarthritis: A national population-based study

Monira Alwhaibi and Tariq M Alhawassi

PLOS ONE, 2025, vol. 20, issue 6, 1-14

Abstract: Background: Adults with osteoarthritis are vulnerable to mental health disorders, which may have a significant impact on their Health-Related Quality of Life (HRQoL). Thus, the purpose of this study was to look at the relationship between anxiety and depression and HRQoL in adults with osteoarthritis. Methods: Adult patients diagnosed with osteoarthritis who were 18 years of age or older were identified using data from the Medical Expenditure Panel Survey for the years 2018–2021. HRQoL was computed using the veteran’s RAND 12-item health survey which has two domains the Physical and Mental Component Summary (PCS & MCS) ratings. The link between anxiety and depression and HRQoL in individuals with osteoarthritis was examined using multivariable linear regression after the adjustment for a variety of covariates. Results: Of the 3,658 individuals with osteoarthritis that were identified, 12.0% experienced depression, 12.5% had anxiety, and 9.9% had both illnesses. The PCS and MCS mean scores of the HRQoL were lowest for persons with comorbid depression and anxiety compared to adults with osteoarthritis only. Moreover, from the adjusted regression analysis, adults with osteoarthritis who had depression (MCS: adjusted β = −5.408, p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0325780

DOI: 10.1371/journal.pone.0325780

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