Impact of monitor unit optimization in volumetric modulated arc therapy planning for nasopharyngeal carcinoma

Huaqu Zeng, Zhen Li, Zongyou Chen, Shukui Tang, Qifu Lin, Minzhi Zhong and Zunbei Wen

PLOS ONE, 2025, vol. 20, issue 6, 1-15

Abstract: Purpose: To evaluate the impact of monitor units (MUs) optimization on volumetric modulated arc therapy (VMAT) plan for nasopharyngeal carcinoma (NPC). Methods: Twenty-one NPC patients were retrospectively analyzed. Dual-arc VMAT plan were designed using photon optimization algorithms without the monitor unit objective (MUO) tool, denoted as the base plan. Each base plan was re-optimized with the MUO tool with the Maximum MU parameter set to 30% of the base plans’ total MUs and Strength parameters set to 50, 80, and 100, generating plans S50, S80, and S100. Target and organ-at-risk (OAR) dose distributions, MUs, beam delivery time, and gamma passing rates were compared between re-optimized and base plans. Statistical analysis was performed using SPSS 17.0 (paired t-tests; significance: P 4% (relative to the base plan) in four patients. Plan S80 reduced target PGTV and PGTVnd Dmax and target PCTV2 D98% for >3% but

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0327153 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 27153&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0327153

DOI: 10.1371/journal.pone.0327153

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().