Epidemiological characteristics and management of Gram-negative bacteraemia in different immunocompromised hosts: Observational single-center study

Alice Toschi, Renato Pascale, Dino Gibertoni, Riccardo Pasquali, Andrea Grechi, Irene Grassi, Marta Malosso, Ludovica Mangione, Cecilia Bonazzetti, Beatrice Tazza, Matteo Rinaldi, Armando Amicucci, Caterina Campoli, Zeno Pasquini, Simone Ambretti, Pier Giorgio Cojutti, Francesca Bonifazi, Pierluigi Viale and Maddalena Giannella

PLOS ONE, 2025, vol. 20, issue 7, 1-14

Abstract: Importance: Patients with Gram-negative bloodstream infections (GN-BSI) are classified as non-immunocompromised (n-IC) or immunocompromised (IC). However, immunosuppressive condition should not be considered univocally. Objective: To investigate epidemiological characteristics, management and outcome of GN-BSI in IC and non-IC patients. Methods: Retrospective single-center study of hospitalized patients with GN-BSI conducted over a 7-year period. Patients with GN-BSI were divided in: solid organ transplant (SOT) recipients, patients with hematologic malignancy (HM), patients with metastatic solid cancer (mSC), and non-major IC patients (nm-IC). Results: 3544 patients analysed: 76.7% nm-IC, 6.5% SOT, 8.0% HM and 8.8% mSC. SOT and HM patients were younger (SOT: 56.6 ± 13.1 years; HM: 56.4 ± 14.5; nm-IC: 72.4 ± 16.1; mSC: 68.6 ± 13.1, p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0327535

DOI: 10.1371/journal.pone.0327535

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