Non-linear association between life’s essential 8 score and depression in middle-aged and older adults with chronic obstructive pulmonary disease

Yushan Shi, Di Huang, Linlin Qu, Qingyin Liu, Zhanjun Qiu and Xianhai Chen

PLOS ONE, 2025, vol. 20, issue 7, 1-14

Abstract: Objective: Relatively few studies have investigated the link between the Life’s Essential 8 (LE8) score and depression among individuals with Chronic Obstructive Pulmonary Disease (COPD). Our objective was to explore the potential association between the LE8 score and the presence of depression in adults aged ≥40 years who diagnosed with COPD. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005–2018 was used in this study. Weighted logistic regressions, restricted cubic splines (RCS) were utilized to investigate the correlation between LE8 score and depression. Using a two-piecewise logistic regression model to identify potential threshold effects. Subgroups and sensitivity analyses were conducted to test the robust of the association. Results: The study encompassed a total of 1,110 subjects diagnosed with COPD. In fully adjusted statistical model, an increment of 10 points in the LE8 score was correlated with a reduced likelihood of depression (OR: 0.68, 95% CI: 0.58–0.78). Similar trends in the associations of health behavior score (OR = 0.75, 95% CI: 0.67–0.84) with depression was also identified. The threshold for the LE8 score was pinpointed at 50.0; surpassing this value, the probability of depression decreased by 8.0% for each additional point in the LE8 score (OR, 0.92; 95% CI: 0.88–0.95; P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0327877

DOI: 10.1371/journal.pone.0327877

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