Exploring the association between socioeconomic status and cardiopulmonary exercise testing measures: A cohort study based on routinely collected data

Donna Shrestha, Nicholas A Wisely, Theodoros M Bampouras, Daren A Subar, Cliff Shelton and Christopher J Gaffney

PLOS ONE, 2025, vol. 20, issue 8, 1-17

Abstract: Background: Cardiopulmonary exercise testing (CPET) provides objective measures of cardiorespiratory fitness and can support surgical risk stratification. As socioeconomic status is a factor known to influence patient health and outcomes, we analysed how CPET-derived measures vary across levels of socioeconomic status in patients being considered for elective surgery. Methods: A database of patients who underwent CPET between 2011 and 2024 was analysed. Measures including oxygen consumption (V̇O₂) at gas exchange threshold (GET), peak V̇O₂, and ventilatory equivalent for carbon dioxide (VE/V̇CO₂) were compared across socioeconomic deprivation quintiles. Multivariable linear and logistic regression models assessed the effects of age, sex, body mass index (BMI), Revised Cardiac Risk Index (RCRI), and deprivation quintiles on CPET measures. Hierarchical regression models incorporating the Indices of Deprivation (IoD) domains and Access to Healthy Assets and Hazards (AHAH) scores determined whether wider social determinants of health explained the variance in CPET measures. Results: A total of 3344 patients (2476 male) were included, referred prior to procedures in vascular (2006), colorectal (650), upper GI (267), urology (205), and other (216) surgical specialties. Lower socioeconomic status was associated with younger age (p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0328056

DOI: 10.1371/journal.pone.0328056

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