CaOx crystal nuclei are formed in rat outer cortex proximal tubules by a potential fibrinogen-dependent mechanism

Kenshirou Kunii, Shigeru Sugiki, Chiharuko Ushimoto, Shinya Inoue, Nobuyo Morita, Yuka Nakamura, Tetsuhiro Horie, Takuya Sakamoto, Hiromi Sakata-Haga, Jia Han, Toshihisa Hatta, Yasuhito Ishigaki, Sohsuke Yamada and Katsuhito Miyazawa

PLOS ONE, 2025, vol. 20, issue 9, 1-20

Abstract: Calcium oxalate (CaOx) stones are prevalent in urinary tract stone disease. While their formation can be induced in rats by administering ethylene glycol and vitamin D, the initial nucleation and formation processes are unclear. Here, we aimed to determine where CaOx crystals initially form, examine the associated histological and morphological changes, and clarify the genes whose expression varies at those sites and their function. Male Wistar rats were divided into four groups: control, ethylene glycol, vitamin D, and ethylene glycol plus vitamin D (EG + VitD). Crystal development locations were mapped on kidney tissue sections, and the initial crystal site distribution was revealed. CaOx crystal formation was observed only in the EG + VitD group kidneys, predominantly in the proximal tubules in the outer renal cortex. The tubular luminal area was significantly increased (P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0328721

DOI: 10.1371/journal.pone.0328721

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