Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases

Gohar Azhar, Ambika Verma, Pankaj Patyal, Wei Zhang, Shakshi Sharma, Patricia E Savary, Sheldon Riklon, Philmar Mendoza Kabua, Pearl A McElfish and Jeanne Y Wei

PLOS ONE, 2025, vol. 20, issue 8, 1-17

Abstract: The Marshallese communities face disproportionately high prevalence of chronic diseases, including diabetes, obesity, cardiovascular disease, and inflammatory conditions. Differences in miRNA expression may contribute to investigate the potential risk of chronic diseases in Marshallese people. In this study, we used RNA isolated from blood samples of Marshallese participants that resides in Arkansas to perform miRNA expression profiling and differential expression analysis. Specifically, blood samples were collected from 47 Marshallese participants after obtaining written informed consent and were subjected to Illumina-based next-generation RNA sequencing. Using the miRBase database, we identified the miRNAs that were most significantly expressed based on log2 fold change values, applying a Bonferroni-corrected P-value threshold of

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0329321

DOI: 10.1371/journal.pone.0329321

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