Corneal biomechanical predictors of intraocular pressure elevation after intravitreal anti-VEGF injection

Sayaka Sumi, Ryo Asaoka, Shuichiro Aoki, Kohdai Kitamoto, Ryo Terao, Mariko Kawata, Tatsuya Inoue, Ryo Obata and Keiko Azuma

PLOS ONE, 2025, vol. 20, issue 8, 1-10

Abstract: Purpose: To investigate whether corneal biomechanical parameters measured via Corvis ST can predict acute intraocular pressure (IOP) elevation following intravitreal anti-VEGF injection. Design: Retrospective observational study. Subjects: Forty eyes from patients with neovascular age-related macular degeneration or retinal vein occlusion who underwent anti-VEGF therapy. Methods: IOP was measured using the Corvis ST immediately before and 10 minutes after injection. The following biomechanical parameters were evaluated: DA Ratio MAX (2mm), biomechanically corrected IOP (bIOP), Peak Distance, Deflection Amplitude Max, Integrated Radius, and Stress-Strain Index (SSI). Main outcome measures: Acute post-injection IOP elevation (continuous) and IOP spikes ≥10 mmHg (binary). Results: The mean IOP increased significantly from 14.5 ± 3.17 to 24.7 ± 7.44 mmHg post-injection (p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0330574

DOI: 10.1371/journal.pone.0330574

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