Insulin resistance markers HOMA-IR, TyG and TyG-BMI index in relation to heart failure risk: NHANES 2011-2016

Meijuan Lu, Junchi Guo, Peili Yang, Teng Ma and Mingyan Zhang

PLOS ONE, 2025, vol. 20, issue 9, 1-17

Abstract: Background: Insulin resistance (IR) is increasingly recognized as an important factor in the development of heart failure (HF). This study aimed to evaluate the association and predictive ability of three IR markers—HOMA-IR, TyG, and TyG-BMI index—with HF risk. Methods: Data from 7,668 participants in the NHANES 2011–2016 survey were analyzed. Multivariable logistic regression was used to assess the relationship between HOMA-IR, TyG, and TyG-BMI with HF incidence, adjusting for potential confounders. Receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and restricted cubic spline (RCS) analysis were conducted to compare the predictive performance of the three markers. Results: HOMA-IR (OR = 1.017, 95% CI: 1.006–1.027, P

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0331740 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 31740&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0331740

DOI: 10.1371/journal.pone.0331740

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().