Comparative effectiveness of adjuvant treatment for hepatocellular carcinoma with high risk of recurrence: A systematic review and network meta-analysis

Zha Peng, Leigu Shen, Yaqiong Wang, Boyu Chen, Zhuangrong Zhu, Chengyi He and Hai Huang

PLOS ONE, 2025, vol. 20, issue 12, 1-17

Abstract: Objective: To identify the most effective postoperative intervention regimen for persons with hepatocellular carcinoma (HCC) at high risk of recurrence. Methods: A network meta-analysis was conducted by collecting eligible studies from Medline, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases. Pairwise and network meta-analyses were applied to pooled data on overall survival (OS) and recurrence-free survival (RFS). Results: 35 studies involving 6,372 patients were analyzed. Pairwise meta-analysis showed higher OS (HR = 0.64, 95% CI: 0.56–0.72; P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0335457

DOI: 10.1371/journal.pone.0335457

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