Evaluation of the insulin-dependent and -independent hypoglycemic effects and understanding their breakdown in the progression of obesity using mice

Fusako Kojima, So Morishita, Shinsuke Uda, Noriko Yutsudo, Yoshihiro Ogawa and Hiroyuki Kubota

PLOS ONE, 2025, vol. 20, issue 12, 1-22

Abstract: Temporal changes in blood glucose levels are useful in assessing glucose tolerance. While blood glucose levels are known to be tightly regulated by insulin-dependent and -independent (glucose effectiveness) hypoglycemic effects, their temporal changes and the organs involved have not been sufficiently explored. This study showed how the relative strengths of these effects change over time during the glucose clamp test, using biological experiments and a mathematical model. We found that the glucose effectiveness exhibited a transient effect within 60 min, whereas the insulin-dependent effect showed a sustained effect intensified after 60 min. Additionally, we found that the liver and muscles were responsible for glucose effectiveness and insulin-dependent hypoglycemic effects, respectively. We applied this model to obese mice and found that both hypoglycemic effects decreased as obesity progressed. These results provide insights into hypoglycemic effects and have important implications for the assessment and interpretation of glucose tolerance in mice.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0337739 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 37739&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0337739

DOI: 10.1371/journal.pone.0337739

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().