Multimorbidity and cancer treatment among the older patients in the United States

Tung Thanh Pham, Avonne E Connor and Anne F Rositch

PLOS ONE, 2026, vol. 21, issue 1, 1-15

Abstract: Introduction: The number of individuals who are diagnosed with cancer and other comorbidities continues to increase, and the average number of comorbidities among racial/ethnic minority patients is higher than non-Hispanic (N.H.)-white patients. Therefore, we explored the association between race/ethnicity, comorbidities, and cancer treatment among older Americans diagnosed with the four most common cancer types. Methods: In this retrospective cohort study, SEER-Medicare linked data were used to identify 692,159 individuals over 65 years old diagnosed with female breast, colorectal, lung, or prostate cancer from 1992–2011. Multimorbidity was defined as having cancer plus two or more comorbidities. Modified Poisson regression models were used to assess the association between comorbidities and race/ethnicity on cancer treatment within 6 months of diagnosis. Results: For all cancers, the percentage of patients receiving treatment declined over time and with increasing age, number of comorbidities, and advanced cancer stage. Variability in receipt of treatment by race/ethnicity was observed: 76% for NH-White, 75% for Hispanic, and 68% for NH-Black patients. Concurrently, multimorbidity was increasing over time for all patients. Adjusting for other covariates, patients with multimorbidity were less likely to receive cancer treatment (RR = 0.987–0.947, all p-value

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0338721

DOI: 10.1371/journal.pone.0338721

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