The prognostic value of gait speed in hemodialysis patients: A prospective observational study

Joyce Noelly Vitor Santos, Vanessa Gomes Brandão Rodrigues, Redha Taiar, Tamara Cunha, Elisângela Andrade Assis Madeira, Inara Caroline Marcelino Martins, Maria Cecília Sales Mendes Prates, Vanessa Kelly da Silva Lage, Ana Cristina Rodrigues Lacerda, Henrique Silveira Costa, Frederico Lopes Alves, Emílio Henrique Barroso Maciel, Pedro Henrique Scheidt Figueiredo and Vanessa Amaral Mendonça

PLOS ONE, 2026, vol. 21, issue 3, 1-11

Abstract: Background: Gait speed has emerged as a sensitive and practical measure of functional status, and its association with overall health and adverse outcomes in various populations has been increasingly recognized. However, its prognostic value among hemodialysis patients remains insufficiently explored. Objective: To assess the prognostic value of the gait speed in hemodialysis patients. Methods: This prospective observational study assessed adults with end-stage renal disease on hemodialysis. Baseline measurements were taken from April 2019 onward, and survival was observed until December 2024. Usual walking speed was measured by an 8-meter gait speed protocol, with the time to cover the central 4-meter distance recorded. Also, established prognostic factors were evaluated. Data were analyzed using the Cox regression analysis and the ROC curve. The Kaplan-Meier curve compared the cumulative survival across gait speed categories. Statistical significance was set at 5%. Results: A total of 120 eligible patients were included. Age (HR 1.05 [95% CI 1.01–1.09], p = 0.01), phosphorus (HR 0.72 [95% CI 0.54–0.96], p = 0.03), and gait speed (HR 0.04 [95% CI 0.01–0.14], p

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0343612

DOI: 10.1371/journal.pone.0343612

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