Trends in recorded deaths involving antipsychotics: The role of deprivation, ethnicity, and regional disparities

Muhammad Umair Khan and Syed Shahzad Hasan

PLOS ONE, 2026, vol. 21, issue 6, 1-14

Abstract: Objective: The relationship between antipsychotic use and mortality remains uncertain, with evidence suggesting both potential risks and benefits. This study aimed to examine trends in recorded deaths involving antipsychotics in England and to explore regional, socioeconomic, and ethnic variation in these patterns. Methods: A population-level analysis of NHS prescription data (2015–2023) across seven regions of NHS England used linear regression and generalised additive models (GAMs) to explore associations between recorded deaths involving antipsychotics and deprivation, ethnic density, and regional variation. Results: Recorded deaths involving antipsychotics increased from 10.33 to 13.85 deaths per million prescription items between 2015 and 2023 (p

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0349877

DOI: 10.1371/journal.pone.0349877

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