Efficacy of adjunctive antibiotics compared to non-antibiotic therapies following mechanical debridement for peri-implantitis: A systematic review and meta-analysis of randomized controlled trials

Caiyun Liu, Hongtao Wang, Yulan Li, Zhilong Huang, Jian Sun and Han Cai

PLOS ONE, 2026, vol. 21, issue 6, 1-19

Abstract: Objective: To evaluate the efficacy of antibiotic therapy as an adjunct to mechanical debridement in peri-implantitis. Method: PubMed, Embase, Web of Science, the Cochrane Library, and Scopus were searched (inception to 15 January, 2026). Additionally, clinical trials were searched on ClinicalTrials.gov. Meta-analyses were performed to evaluate bone level (BL), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), modified plaque index (mPLI), plaque score (PS). Results: Twenty-two RCTs were included. Adjunctive antibiotics with mechanical debridement demonstrated significant advantages in improving PPD (WMD = −0.69; 95% CI: [−1.04, −0.33]; P = 0.0001; heterogeneity:I2 = 91%, P

Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0352311 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 52311&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0352311

DOI: 10.1371/journal.pone.0352311

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().