Association of uric acid and red blood cell distribution width with severe obstructive sleep apnea–hypopnea syndrome in middle-aged males

Tingting Zhou, Hongyan Tao, Hong Wang and Fengxian Wei

PLOS ONE, 2026, vol. 21, issue 7, 1-10

Abstract: Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is sleep-related breathing disorder with high prevalence. Polysomnography is the gold diagnosis standard. Routine clinical biomarkers would assist to reflect disease severity. Our study aimed to explore the association between hematological parameters and newly diagnosed severe OSAHS in middle-aged males. Methods: This retrospective study enrolled 132 cases (40 ~ 65 years). Patients were divided into non-severe group (n = 69) and severe group (n = 63) based on the apnea-hypopnea index (AHI). Hematological parameters were compared between the two groups. Unitarian and multivariate logistic regression were performed to identify factors independently correlated with severe OSAHS. Receiver operating characteristic (ROC) curve analysis was performed to evaluate discriminative performance. Spearman correlation and multiple linear regression were utilized to investigate correlated factors with sleep hypoxia. Results: Significantly higher hemoglobin, hematocrit (HCT), mean corpuscular volume (MCV), red blood cell distribution width-standard deviation (RDW-SD), and uric acid were found in the severe group than the non-severe group (all P

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0354161

DOI: 10.1371/journal.pone.0354161

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