Impact of revised antral follicle count threshold on PCOS diagnosis: A comparative clinical study

Saloni Kamboj, Neena Malhotra, Reeta Mahey, Taruna Arora, Aditi Goyal, Snigdha Soni, Anshu Jyoti, Spondita Banerjee and Rintu Kutum

PLOS ONE, 2026, vol. 21, issue 10, 1-11

Abstract: Objective: To evaluate the clinical impact of the revised antral follicle count (AFC) threshold on polycystic ovary syndrome (PCOS) diagnosis. Methods: A retrospective cross-sectional observational study including women diagnosed using the Rotterdam criteria, stratified by AFC: 12–19 (low AFC) and ≥20 (high AFC). Clinical, metabolic, and hormonal parameters were compared against controls and amongst low and high AFC group. Results: Of 336 PCOS women, 208 (62%) had an AFC between 12 and 19 and would not meet the revised ≥20 follicle threshold for the diagnosis of polycystic morphology. These women had worse metabolic and androgenic profiles than controls, and were similar to the high AFC group. Conclusion: Excluding low AFC women may misclassify patients who require clinical care.

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0358554

DOI: 10.1371/journal.pone.0358554

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