Is resistance training effective to increase BDNF in multiple sclerosis? An updated systematic review and meta-analysis of isolated interventions

William Riciere Pedon, Gustavo De Conti Teixeira Costa, Lorenzo de Ávila Rodrigues Cortizo Vidal, Pedro Augusto Inacio, Marcelo Magalhães Sales, Ivanéria Mendonça Martins, James Oluwagbamigbe Fajemiroye, Sergio Machado, Vicente Aprigliano, Gabriela Ribeiro Inacio, Adolfo Mundombe Cameia, Gaspar R Chiappa, Eduardo da Matta Mello Portugal and Alberto Souza Sá Filho

PLOS ONE, 2026, vol. 21, issue 10, 1-17

Abstract: Background: Brain-derived neurotrophic factor (BDNF) is a key mediator of neuroplasticity and has been associated with disease progression in multiple sclerosis (MS). While aerobic exercise is consistently linked to BDNF modulation, the specific contribution of isolated resistance training (RT) remains unclear, as previous reviews have largely combined multimodal exercise interventions. Objective: To systematically review and meta-analyze the effects of isolated RT on peripheral BDNF levels in individuals with MS (PROSPERO: CRD420251141069). Methods: Searches were conducted in PubMed, Web of Science, Scielo, Scopus, PEDro and Cochrane up to January 10, 2026, using PICOT criteria. Controlled experimental studies investigating isolated RT and BDNF outcomes were included. Risk of bias was assessed using RoB 2.0 and ROBINS-I, and certainty of evidence was evaluated using GRADE. Due to methodological heterogeneity, a random-effects model was applied to estimate pooled effects. Results: Four studies (three RCTs and one controlled non-randomized trial), totaling 126 participants with MS, were included. Interventions lasted 8–24 weeks, with training frequencies of 2–3 sessions per week. Meta-analytic synthesis revealed positive pooled effects (SMD = 0.49; 95%CI: 0.15 to 0.83; Z = 2.80; p

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0359019

DOI: 10.1371/journal.pone.0359019

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