Cardiovascular disease mortality in a Central-West Brazilian capital: A spatial, temporal, and ecological analysis

João Vitor Barrio, Rafael Santana Batista Cabral, Sonia Regina Maciel Rodrigues da Silva, Audêncio Victor, Maria Elizabeth Araújo Ajalla, Cláudia Du Bocage Santos-Pinto and Everton Falcão de Oliveira

PLOS ONE, 2026, vol. 21, issue 9, 1-20

Abstract: In Brazil, regional disparities in cardiovascular disease (CVD) mortality persist, with no population-based study having examined CVD mortality at the municipal level in the Central-West region. This study analysed the epidemiological profile, temporal trends, spatial distribution, and socioeconomic correlates of CVD mortality in Campo Grande, Mato Grosso do Sul, Brazil (2013–2022). A population-based ecological study used data from the Brazilian Mortality Information System. Five CVD groups were analysed: ischaemic heart disease (IHD), heart failure (HF), arrhythmias (ARR), cardiomyopathies (CMP), and inflammatory heart diseases (INF). Temporal trends were assessed using Poisson, Prais-Winsten, and Joinpoint regression. Spatial distribution was examined through Kernel Density Estimation and Local Indicators of Spatial Association (LISA). Socioeconomic correlates were assessed using Spearman’s correlation with neighbourhood-level indicators. Of 59,392 registered deaths, 8,148 (13.7%) were CVD-related. IHD was the dominant cause (79.5%), with males accounting for 59.3% of deaths (IRR 1.59; 95% CI 1.46–1.74) and individuals aged ≥60 years representing 75.2%. Overall crude CVD mortality increased by 26.1% over the study period, with an estimated mean annual increase of 2.5% (APC + 2.5%/year; 95% CI 1.7–3.3; p

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0359337

DOI: 10.1371/journal.pone.0359337

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