PLOS Pathogens

2005 - 2025

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Volume 21, issue 4, 2025

The molecular basis for DNA-binding by competence T4P is distinct in a representative Gram-positive and Gram-negative species pp. 1-19

Nicholas D Christman and Ankur B Dalia

Volume 21, issue 3, 2025

Selection and characterization of a broadly neutralizing class of HCV anti-E2 VH1-69 antibodies pp. 1-23

Andreas Soerensen, Filip Popovic, Christina Holmboe Olesen, Blanca Lopez Mendez, Brian Lohse, Zhaochun Chen, Patrizia Farci, Robert H Purcell, Harvey J Alter, Lea Klingenberg Barfod, Jens Bukh and Jannick Prentoe

Volume 20, issue 12, 2024

TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages pp. 1-22

Moe Kobayashi, Nene Kobayashi, Kyoka Deguchi, Seira Omori, Minami Nagai, Ryutaro Fukui, Isaiah Song, Shinji Fukuda, Kensuke Miyake and Takeshi Ichinohe

Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression pp. 1-31

Marloes Grobben, Margreet Bakker, Angela I Schriek, Liesbeth JJ Levels, Jeffrey C Umotoy, Khadija Tejjani, Mariëlle J van Breemen, Ryan N Lin, Steven W de Taeye, Gabriel Ozorowski, Neeltje A Kootstra, Andrew B Ward, Stephen J Kent, P Mark Hogarth, Bruce D Wines, Rogier W Sanders, Amy W Chung and Marit J van Gils

Volume 20, issue 10, 2024

High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic pp. 1-21

Moira Kelly, Christina A Cuomo, Wouter Beukema, Salvador Carranza, Jesse Erens, Marleen Foubert, Zhimin Li, Stefan Lötters, Vanessa Schulz, Sebastian Steinfartz, Sarah Van Praet, Michael Veith, Frank Pasmans and An Martel

Volume 20, issue 9, 2024

Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays pp. 1-24

Ankit Srivastava, Qinlu Wang, Christina D Orrù, Manel Fernandez, Yaroslau Compta, Bernardino Ghetti, Gianluigi Zanusso, Wen-Quan Zou, Byron Caughey and Catherine A A Beauchemin

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal pp. 1-32

William J Cisneros, Shimaa H A Soliman, Miriam Walter, Lacy M Simons, Daphne Cornish, Simone De Fabritiis, Ariel W Halle, Eun-Young Kim, Steven M Wolinsky, Ramon Lorenzo-Redondo, Ali Shilatifard and Judd F Hultquist

Volume 20, issue 8, 2024

Data alchemy, from lab to insight: Transforming in vivo experiments into data science gold pp. 1-7

Troy J Kieran, Taronna R Maines and Jessica A Belser

Volume 20, issue 7, 2024

Influenza A viral burst size from thousands of infected single cells using droplet quantitative PCR (dqPCR) pp. 1-23

Geoffrey K Zath, Mallory M Thomas, Emma K Loveday, Dimitri A Bikos, Steven Sanche, Ruian Ke, Christopher B Brooke and Connie B Chang

Volume 20, issue 6, 2024

CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan pp. 1-28

Linda Heilig, Fariha Natasha, Nora Trinks, Vishukumar Aimanianda, Sarah Sze Wah Wong, Thierry Fontaine, Ulrich Terpitz, Lea Strobel, François Le Mauff, Donald C Sheppard, Sascha Schäuble, Oliver Kurzai, Kerstin Hünniger, Esther Weiss, Mario Vargas, P Lynne Howell, Gianni Panagiotou, Sebastian Wurster, Hermann Einsele and Juergen Loeffler

Zinc-finger (ZiF) fold secreted effectors form a functionally diverse family across lineages of the blast fungus Magnaporthe oryzae pp. 1-25

Juan Carlos De la Concepcion, Thorsten Langner, Koki Fujisaki, Xia Yan, Vincent Were, Anson Ho Ching Lam, Indira Saado, Helen J Brabham, Joe Win, Kentaro Yoshida, Nicholas J Talbot, Ryohei Terauchi, Sophien Kamoun and Mark J Banfield

IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission pp. 1-27

Arun Prakash, Florence Fenner, Biswajit Shit, Tiina S Salminen, Katy M Monteith, Imroze Khan and Pedro F Vale

Volume 20, issue 5, 2024

Meta-analysis of Epstein-Barr virus genomes in Southern Chinese identifies genetic variants and high risk viral lineage associated with nasopharyngeal carcinoma pp. 1-19

Ka Wo Wong, Kwai Fung Hui, Ki Pui Lam, Dora Lai-wan Kwong, Maria Li Lung, Wanling Yang and Alan K S Chiang

Volume 20, issue 4, 2024

Small RNA SmsR1 modulates acidogenicity and cariogenic virulence by affecting protein acetylation in Streptococcus mutans pp. 1-24

Jing Li, Qizhao Ma, Jun Huang, Yaqi Liu, Jing Zhou, Shuxing Yu, Qiong Zhang, Yongwang Lin, Lingyun Wang, Jing Zou and Yuqing Li

Predicting the presence of infectious virus from PCR data: A meta-analysis of SARS-CoV-2 in non-human primates pp. 1-39

Celine E Snedden and James O Lloyd-Smith

Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics pp. 1-28

Rebecca M Johnson, Isaac J Stopard, Helen M Byrne, Philip M Armstrong, Douglas E Brackney and Ben Lambert

Dynamic changes of Bacterial Microbiomes in Oropharynx during Infection and Recovery of COVID-19 Omicron Variant pp. 1-26

Guangying Cui, Ying Sun, Yawen Zou, Ranran Sun, Yanxia Gao, Xiaorui Liu, Yongjian Zhou, Donghua Zhang, Xueqing Wang, Yonghong Li, Liwen Liu, Guizhen Zhang, Benchen Rao, Zujiang Yu and Zhigang Ren

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context pp. 1-26

Iris Mair, Jonathan Fenn, Andrew Wolfenden, Ann E Lowe, Alex Bennett, Andrew Muir, Jacob Thompson, Olive Dieumerci, Larisa Logunova, Susanne Shultz, Janette E Bradley and Kathryn J Else

Beyond the VSG layer: Exploring the role of intrinsic disorder in the invariant surface glycoproteins of African trypanosomes pp. 1-23

Hagen Sülzen, Alexander N Volkov, Rob Geens, Farnaz Zahedifard, Benoit Stijlemans, Martin Zoltner, Stefan Magez, Yann G-J Sterckx and Sebastian Zoll

Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review pp. 1-19

Naomi M Fuller, Christopher F McQuaid, Martin J Harker, Chathika K Weerasuriya, Timothy D McHugh and Gwenan M Knight

Lineage frequency time series reveal elevated levels of genetic drift in SARS-CoV-2 transmission in England pp. 1-37

QinQin Yu, Joao A Ascensao, Takashi Okada, The COVID-19 Genomics UK (COG-UK) Consortium, Olivia Boyd, Erik Volz and Oskar Hallatschek

Volume 20, issue 1, 2024

Trained immunity in recurrent Staphylococcus aureus infection promotes bacterial persistence pp. 1-22

Xiao-Qi Lin, Zhen-Zhen Liu, Cheng-Kai Zhou, Liang Zhang, Yu Gao, Xue-Yue Luo, Jian-Gang Zhang, Wei Chen and Yong-Jun Yang

Volume 19, issue 12, 2023

Regulation of human neutrophil IL-1β secretion induced by Escherichia coli O157:H7 responsible for hemolytic uremic syndrome pp. 1-24

Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Alexia Vereertbrugghen, Douglas Vera Aguilar, Paolo Nahuel Rubatto Birri, Manuela Pizzano, María Victoria Ramos, Federico Fuentes, Lucas Saposnik, Agostina Cernutto, Juliana Cassataro, Carolina Cristina Jancic, Jeremías Gaston Galletti, Marina Sandra Palermo and Analía Silvina Trevani

Volume 19, issue 10, 2023

Prevention of zoonotic spillover: From relying on response to reducing the risk at source pp. 1-8

Authored by the members of the One Health High-Level Expert Panel (ohhlep), Wanda Markotter, Thomas C Mettenleiter, Wiku B Adisasmito, Salama Almuhairi, Casey Barton Behravesh, Pépé Bilivogui, Salome A Bukachi, Natalia Casas, Natalia Cediel Becerra, Dominique F Charron, Abhishek Chaudhary, Janice R Ciacci Zanella, Andrew A Cunningham, Osman Dar, Nitish Debnath, Baptiste Dungu, Elmoubasher Farag, George F Gao, David T S Hayman, Margaret Khaitsa, Marion P G Koopmans, Catherine Machalaba, John S Mackenzie, Serge Morand, Vyacheslav Smolenskiy and Lei Zhou

The Aspergillus fumigatus UPR is variably activated across nutrient and host environments and is critical for the establishment of corneal infection pp. 1-32

Manali M Kamath, Jorge D Lightfoot, Emily M Adams, Ryan M Kiser, Becca L Wells and Kevin K Fuller

Volume 19, issue 9, 2023

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo pp. 1-23

Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramaugé Parra, Etienne Kornobis, Eliette Bonnefoy and Xavier Montagutelli

Volume 19, issue 8, 2023

Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias pp. 1-24

Helen R Fryer, Tanya Golubchik, Matthew Hall, Christophe Fraser, Robert Hinch, Luca Ferretti, Laura Thomson, Anel Nurtay, Lorenzo Pellis, Thomas House, George MacIntyre-Cockett, Amy Trebes, David Buck, Paolo Piazza, Angie Green, Lorne J Lonie, Darren Smith, Matthew Bashton, Matthew Crown, Andrew Nelson, Clare M McCann, Mohammed Adnan Tariq, Claire J Elstob, Rui Nunes Dos Santos, Zack Richards, Xin Xhang, Joseph Hawley, Mark R Lee, Priscilla Carrillo-Barragan, Isobel Chapman, Sarah Harthern-Flint, The COVID-19 Genomics UK (COG-UK) Consortium, David Bonsall and Katrina A Lythgoe

Volume 19, issue 7, 2023

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression pp. 1-25

Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Renata B Filler, Scott B Biering, Sylvia A Sarnik, Sonam Patel, Bridget L Menasche, Susan R Compton, Silvana Konermann, Patrick D Hsu, Robert C Orchard, Qin Yan and Craig B Wilen

Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire pp. 1-23

Allister Irvine, Darrin McKenzie, Ciaran J McCoy, Robert L J Graham, Ciaren Graham, Sharon A Huws, Louise E Atkinson and Angela Mousley

Volume 19, issue 6, 2023

Neutralization profiles of HIV-1 viruses from the VRC01 Antibody Mediated Prevention (AMP) trials pp. 1-17

Nonhlanhla N Mkhize, Anna E J Yssel, Haajira Kaldine, Rebecca T van Dorsten, Amanda S Woodward Davis, Nicolas Beaume, David Matten, Bronwen Lambson, Tandile Modise, Prudence Kgagudi, Talita York, Dylan H Westfall, Elena E Giorgi, Bette Korber, Colin Anthony, Rutendo E Mapengo, Valerie Bekker, Elizabeth Domin, Amanda Eaton, Wenjie Deng, Allan DeCamp, Yunda Huang, Peter B Gilbert, Asanda Gwashu-Nyangiwe, Ruwayhida Thebus, Nonkululeko Ndabambi, Dieter Mielke, Nyaradzo Mgodi, Shelly Karuna, Srilatha Edupuganti, Michael S Seaman, Lawrence Corey, Myron S Cohen, John Hural, M Juliana McElrath, James I Mullins, David Montefiori, Penny L Moore, Carolyn Williamson and Lynn Morris

Advancing the central role of non-model biorepositories in predictive modeling of emerging pathogens pp. 1-8

Jocelyn P Colella, Marlon E Cobos, Irene Salinas, Joseph A Cook and The PICANTE Consortium

Volume 19, issue 5, 2023

α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification pp. 1-29

Manisha Naskar, Viraj P Parekh, Mathew A Abraham, Zehra Alibasic, Min Jung Kim, Gyeongseo Suk, Joo Hwan Noh, Kwan Young Ko, Joonha Lee, Chungho Kim, Hana Yoon, Soman N Abraham and Hae Woong Choi

Volume 19, issue 1, 2023

Race and ethnicity: Risk factors for fungal infections? pp. 1-22

Jeffrey D Jenks, Chioma Inyang Aneke, Mohanad M Al-Obaidi, Matthias Egger, Lorena Garcia, Tommi Gaines, Martin Hoenigl and George R Thompson

Making the best of research investment in pathogens control through biocontrol. How is research correlated with agricultural microbial biological control product availability? pp. 1-8

Florența-Elena Helepciuc and Arpad Todor

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence pp. 1-29

Shishir Singh, Mateo Murillo-León, Niklas Sebastian Endres, Ailan Farid Arenas Soto, Jorge Enrique Gómez-Marín, Florence Melbert, Thirumala-Devi Kanneganti, Masahiro Yamamoto, Claudia Campos, Jonathan Charles Howard, Gregory Alan Taylor and Tobias Steinfeldt

Volume 18, issue 10, 2022

Pestilence and famine: Continuing down the vicious cycle with COVID-19 pp. 1-6

Sudipta Hyder, Rethy K Chhem, Filip Claes and Erik Albert Karlsson

Volume 18, issue 9, 2022

A tRNA-derived fragment present in E. coli OMVs regulates host cell gene expression and proliferation pp. 1-33

Idrissa Diallo, Jeffrey Ho, Marine Lambert, Abderrahim Benmoussa, Zeinab Husseini, David Lalaouna, Eric Massé and Patrick Provost

Volume 18, issue 7, 2022

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation pp. 1-28

Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P Mata, James Krieger, Paula Ruiz-Rodriguez, Maria Luisa López-Redondo, Clara Francés-Gómez, Roberto Melero, Carlos Óscar Sánchez-Sorzano, Marta Martínez, Nadine Gougeard, Alicia Forcada-Nadal, Sara Zamora-Caballero, Roberto Gozalbo-Rovira, Carla Sanz-Frasquet, Rocío Arranz, Jeronimo Bravo, Vicente Rubio, Alberto Marina, The IBV-Covid19-Pipeline, Ron Geller, Iñaki Comas, Carmen Gil, Mireia Coscolla, Modesto Orozco, José Luis Llácer and Jose-Maria Carazo

Volume 18, issue 6, 2022

Longitudinal kinetics of RBD+ antibodies in COVID-19 recovered patients over 14 months pp. 1-20

Tsuf Eyran, Anna Vaisman-Mentesh, David Taussig, Yael Dror, Ligal Aizik, Aya Kigel, Shai Rosenstein, Yael Bahar, Dor Ini, Ran Tur-Kaspa, Tatyana Kournos, Dana Marcoviciu, Dror Dicker and Yariv Wine

Volume 18, issue 5, 2022

Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly pp. 1-30

Sarah van Tol, Birte Kalveram, Philipp A Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria I Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N Warren, Alexander Bukreyev, Alexander N Freiberg and Ricardo Rajsbaum

Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env pp. 1-34

Hannah M Schapiro, Mukta D Khasnis, Koree Ahn, Alexandra Karagiaridi, Stephanie Hayden, Maria E Cilento and Michael J Root

Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas pp. 1-20

Michaela D J Blyton, Michael Pyne, Paul Young and Keith Chappell

Volume 18, issue 4, 2022

Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection pp. 1-31

Guillaume N Fiches, Zhenyu Wu, Dawei Zhou, Ayan Biswas, Tai-Wei Li, Weili Kong, Maxime Jean, Netty G Santoso and Jian Zhu

Volume 18, issue 3, 2022

Acid stress signals are integrated into the σB-dependent general stress response pathway via the stressosome in the food-borne pathogen Listeria monocytogenes pp. 1-25

Duarte N Guerreiro, M Graciela Pucciarelli, Teresa Tiensuu, Diana Gudynaite, Aoife Boyd, Jörgen Johansson, Francisco García-del Portillo and Conor P O’Byrne

Volume 17, issue 12, 2021

Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane pp. 1-20

Vesa Aho, Sami Salminen, Salla Mattola, Alka Gupta, Felix Flomm, Beate Sodeik, Jens B Bosse and Maija Vihinen-Ranta

Volume 17, issue 11, 2021

Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis pp. 1-28

Alexandre Girard, Anneli Cooper, Samuel Mabbott, Barbara Bradley, Steven Asiala, Lauren Jamieson, Caroline Clucas, Paul Capewell, Francesco Marchesi, Matthew P Gibbins, Franziska Hentzschel, Matthias Marti, Juan F Quintana, Paul Garside, Karen Faulds, Annette MacLeod and Duncan Graham

Volume 17, issue 9, 2021

The small acid-soluble proteins of Clostridioides difficile are important for UV resistance and serve as a check point for sporulation pp. 1-28

Hailee N Nerber and Joseph A Sorg

Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data pp. 1-19

Gonché Danesh, Victor Virlogeux, Christophe Ramière, Caroline Charre, Laurent Cotte and Samuel Alizon

Volume 17, issue 8, 2021

Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model pp. 1-17

Pierre Bessière, Marine Wasniewski, Evelyne Picard-Meyer, Alexandre Servat, Thomas Figueroa, Charlotte Foret-Lucas, Amelia Coggon, Sandrine Lesellier, Frank Boué, Nathan Cebron, Blandine Gausserès, Catherine Trumel, Gilles Foucras, Francisco J Salguero, Elodie Monchatre-Leroy and Romain Volmer

Volume 17, issue 6, 2021

Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4 + T cell repertoire pp. 1-34

Ivy K Brown, Nathan Dyjack, Mindy M Miller, Harsha Krovi, Cydney Rios, Rachel Woolaver, Laura Harmacek, Ting-Hui Tu, Brian P O’Connor, Thomas Danhorn, Brian Vestal, Laurent Gapin, Clemencia Pinilla, Max A Seibold, James Scott-Browne, Radleigh G Santos and R Lee Reinhardt

Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition pp. 1-18

Mamun Kabir, Masud Alam, Uma Nayak, Tuhinur Arju, Biplob Hossain, Rubaiya Tarannum, Amena Khatun, Jennifer A White, Jennie Z Ma, Rashidul Haque, William A Petri and Carol A Gilchrist

Volume 17, issue 4, 2021

Intraspecific variation in immune gene expression and heritable symbiont density pp. 1-21

Holly L Nichols, Elliott B Goldstein, Omid Saleh Ziabari and Benjamin J Parker

Volume 17, issue 3, 2021

Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa pp. 1-23

Arnaud Bataille, Habib Salami, Ismaila Seck, Modou Moustapha Lo, Aminata Ba, Mariame Diop, Baba Sall, Coumba Faye, Mbargou Lo, Lanceï Kaba, Youssouf Sidime, Mohamed Keyra, Alpha Oumar Sily Diallo, Mamadou Niang, Cheick Abou Kounta Sidibe, Amadou Sery, Martin Dakouo, Ahmed Bezeid El Mamy, Ahmed Salem El Arbi, Yahya Barry, Ekaterina Isselmou, Habiboullah Habiboullah, Abdellahi Salem Lella, Baba Doumbia, Mohamed Baba Gueya, Caroline Coste, Cécile Squarzoni Diaw, Olivier Kwiatek, Geneviève Libeau and Andrea Apolloni

Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA pp. 1-34

Aftab Nadeem, Athar Alam, Eric Toh, Si Lhyam Myint, Zia ur Rehman, Tao Liu, Marta Bally, Anna Arnqvist, Hui Wang, Jun Zhu, Karina Persson, Bernt Eric Uhlin and Sun Nyunt Wai

Volume 17, issue 2, 2021

Five key aspects of metaproteomics as a tool to understand functional interactions in host-associated microbiomes pp. 1-10

Fernanda Salvato, Robert L Hettich and Manuel Kleiner

Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages pp. 1-20

Olivier Rey, Eve Toulza, Cristian Chaparro, Jean-François Allienne, Julien Kincaid-Smith, Eglantine Mathieu-Begné, Fiona Allan, David Rollinson, Bonnie L Webster and Jérôme Boissier