Type 2 Diabetes Independent of Glycemic Control is Associated With Cognitive Impairments: Findings From NHANES

Rozmin Jiwani, Brittany Dennis, Alfonso L. Neri, Chandler Bess, Sara Espinoza, Jing Wang and Monica C. Serra

Clinical Nursing Research, 2022, vol. 31, issue 7, 1225-1233

Abstract: Examine the association between glycemic control and cognition. Included subjects ≥60 years who participated in the 2013 to 2014 National Health and Nutrition Examination Survey and completed one of the followings: Consortium to Establish a Registry for Alzheimer’s Disease Word List (CERAD-WL), Animal Fluency (AF), Digit Symbol Substitution Test (DSST), and CERAD-Delayed Recall (CERAD-DR). Stratified participants into: No type 2 diabetes (T2D; N  = 557), Controlled T2D ( N  = 41), Uncontrolled T2D ( N  = 120), and Untreated T2D ( N  = 86). Multiple regression was used to examine the association between variables. After adjusting for demographics and cardiovascular risk factors, Uncontrolled T2D was associated with lower DSST (β = −3.164, p  = .04), and Untreated T2D was associated with a trend for having lower CERAD-DR (β = −.496, p  = .06) scores. T2D, independent of glycemic control, is associated with cognitive impairment and this relationship is influenced by modifiable and non-modifiable risk factors.

Keywords: Type 2 diabetes; glycemic control; cognition; NHANES; cardiovascular risk factors (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:sae:clnure:v:31:y:2022:i:7:p:1225-1233

DOI: 10.1177/10547738221100344

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