The Influence of the BDNF Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes

Bin Zeng, Yan Yue, Tingting Liu, Hyochol Ahn and Changwei Li

Clinical Nursing Research, 2022, vol. 31, issue 8, 1462-1471

Abstract: The rs6265 in the brain-derived neurotrophic factor (BDNF) is associated with depression in people with diabetes. Both physical activity (PA) and grip strength are negatively associated with depression. We conducted cross-sectional analyses of the wave 10 survey data for a nationally representative sample of 1,051 diabetes participants of the Health and Retirement Study. Both greater PA (β = −.15) and stronger grip strength (β = −.02) were independently associated with depression. Although the interaction between BDNF rs6265 and PA on depressive symptoms was not significant, the negative PA-depression association was stronger among female non-Met carriers (β = −.19) and male Met carriers (β = −.14). Meanwhile, grip strength was associated with depression only in Met carriers (β = −.04), and similar association was observed in both males and females. In conclusion, female non-Met carriers and male Met carriers may benefit from PA.

Keywords: brain-derived neurotrophic factor; hand strength; exercise; diabetes mellitus; depression; gene-environment interaction (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:sae:clnure:v:31:y:2022:i:8:p:1462-1471

DOI: 10.1177/10547738221119343

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