Decisional Regret in Long-Term Australian Allogeneic Hematopoietic Stem Cell Transplantation Survivors: A Cross-Sectional Survey

Gemma McErlean, Caley Tapp, Lisa Brice, Anisha Pradhan, Nicole Gilroy, Masura Kabir, Matt Greenwood, Stephen R Larsen, John Moore, David Gottlieb, Mark Hertzberg, Louisa Brown, Megan Hogg, Gillian Huang, Christopher Ward and Ian Kerridge

Clinical Nursing Research, 2023, vol. 32, issue 8, 1134-1144

Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an intensive but effective treatment for malignant and non-malignant diseases. However, long-term survival often comes at a cost, with survivors experiencing chronic morbidity and are at risk of relapse and secondary malignancy. This study aimed to describe decisional regret in a large cohort of Australian long-term allo-HSCT survivors. A cross-sectional survey was conducted with 441 adults in New South Wales, assessing quality of life (QoL), psychological, social, demographic, and clinical variables. Less than 10% of survivors expressed regret, with chronic graft-versus-host disease being the most important clinical factor. Psycho-socioeconomic factors such as depression, lower QoL scores, lower household income, higher treatment burden, and not resuming sex post-HSCT were also associated with regret. Findings highlight the need for valid informed consent and ongoing follow-up and support for allo-HSCT survivors dealing with life post-transplant. Nurses and healthcare professionals play a critical role in addressing decisional regret in these patients.

Keywords: decisional regret; psychosocial; bone marrow transplantation; hematopoietic stem cell transplant; survivorship; cancer; allogeneic transplant (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:sae:clnure:v:32:y:2023:i:8:p:1134-1144

DOI: 10.1177/10547738231180337

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