Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition

Gia Han Le, Angela T.H. Kwan, Ziji Guo, Donovan A. Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M. Teopiz, Danica E. Johnson, Hartej Gill, Joshua D. Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D. Rosenblat, Rodrigo B. Mansur, Mehala Subramaniapillai and Roger S. McIntyre

Clinical Nursing Research, 2025, vol. 34, issue 3-4, 143-152

Abstract: Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.

Keywords: post-COVID-19 condition; long COVID; fatigue; cognition; cognitive impairment (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:sae:clnure:v:34:y:2025:i:3-4:p:143-152

DOI: 10.1177/10547738251329412

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