The Systems Theory of Autistogenesis

J. Patrick Malone

SAGE Open, 2012, vol. 2, issue 2, 2158244012444281

Abstract: The systems theory of autistogenesis accounts for genetic and environmental predisposing factors for pervasive developmental disorders. During development, regions of the brain myelinate differentially, even while neuroinflammatory events induce neurological damage. Incorrect dietary ratios of docosahexaenoic acid (DHA) to arachidonic acid (AA) promote developmental aberration characteristic of autism spectrum disorders (ASD), and commercial infant formulae possesses DHA/AA ratios unsuitable for normal brain development in those predisposed. The aromatase gene regulates DHA/AA metabolism and represents a potential biomarker for ASD. Aromatase converts testosterone to estradiol. Estradiol is neuroprotective and a modulator of oxytocin receptors deficient in autism. Neuroprotective DHA is not well synthesized in males and is regulated by estradiol. Therefore, converging evidence indicates that any disturbance to the autistogenic system linking environment to neurobiology and genetics is capable of inducing developmental disorders with gender disparity.

Keywords: aromatase; autism; docosahexaenoic; estradiol; inflammation (search for similar items in EconPapers)
Date: 2012
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://journals.sagepub.com/doi/10.1177/2158244012444281 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:sae:sagope:v:2:y:2012:i:2:p:2158244012444281

DOI: 10.1177/2158244012444281

Access Statistics for this article

More articles in SAGE Open
Bibliographic data for series maintained by SAGE Publications ().