Triadimefon Disrupts Working Memory in the Matching-to-Position Task

John M. Holden, Ethan Hemmelman, Rowan McGlasson, Zaria Smith, Ashley Ruhland and Erin Hoover

SAGE Open, 2018, vol. 8, issue 4, 2158244018805798

Abstract: Triadimefon (TDF) is a fungicide which has psychostimulant properties similar to cocaine and amphetamine. Past studies with psychostimulants suggests that acute exposure leads to disruptions in working memory. In this study, we examined the effects of TDF exposure (relative to corn oil control) on performance in the delayed matching-to-position task in two separate studies using Sprague-Dawley male rats. In both studies, TDF exposure led to significantly poorer performance across delays. TDF shows similar properties to cocaine and amphetamine in terms of disrupting working memory.

Keywords: triadimefon; psychostimulant; cocaine; amphetamine; working memory; matching-to-position; retinoic acid (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:sae:sagope:v:8:y:2018:i:4:p:2158244018805798

DOI: 10.1177/2158244018805798

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