Investigating Potential Gender-Based Differential Item Functioning for Items in the Kansas City Cardiomyopathy Questionnaire (KCCQ) Physical Limitations Domain

Theresa M. Coles (), Li Lin, Kevin Weinfurt, Bryce B. Reeve, John A. Spertus, Robert J. Mentz, Ileana L. Piña, Fraser D. Bocell, Michelle E. Tarver, Anindita Saha and Brittany Caldwell
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Theresa M. Coles: Duke University School of Medicine
Li Lin: Duke University School of Medicine
Kevin Weinfurt: Duke University School of Medicine
Bryce B. Reeve: Duke University School of Medicine
John A. Spertus: University of Missouri-Kansas City
Robert J. Mentz: Duke University Medical Center
Ileana L. Piña: Wayne State University, Central Michigan University
Fraser D. Bocell: U.S. Food and Drug Administration
Michelle E. Tarver: U.S. Food and Drug Administration
Anindita Saha: U.S. Food and Drug Administration
Brittany Caldwell: U.S. Food and Drug Administration

Applied Research in Quality of Life, 2023, vol. 18, issue 4, No 10, 1785-1798

Abstract: Abstract Women with heart failure report worse health-related quality of life on average, than men. This may result from actual differences in care or differing interpretations of and responses to survey questions. We investigated potential gender-based differential item functioning on the Kansas City Cardiomyopathy Questionnaire (KCCQ) Physical Limitations domain. Using data from the HF-ACTION trial, a multicenter, randomized controlled trial of exercise training in patients with chronic heart failure with reduced ejection fraction (661 women, 1670 men), we assessed gender-based differential item functioning using a Wald test based on item response theory and ordinal logistic regression. Both methods evaluated how men and women responded to each KCCQ item after adjusting for physical limitation status. No item exhibited statistically significant differential item functioning using the Wald method. Two items exhibited differential item functioning using the ordinal logistic regression method (KCCQ1e: Climbing a flight of stairs without stopping; KCCQ1f: Hurrying or jogging) (P

Keywords: Heart failure; Women; Patient-reported outcomes; Differential item functioning; Psychometric (search for similar items in EconPapers)
Date: 2023
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DOI: 10.1007/s11482-023-10162-3

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