Age at First Rotavirus Vaccination and Risk of Intussusception in Infants: A Public Health Modeling Analysis

Chee Fu Yung (), Chia Yin Chong and Koh Cheng Thoon
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Chee Fu Yung: KK Women’s and Children’s Hospital
Chia Yin Chong: KK Women’s and Children’s Hospital
Koh Cheng Thoon: KK Women’s and Children’s Hospital

Drug Safety, 2016, vol. 39, issue 8, No 4, 745-748

Abstract: Abstract Introduction The epidemiology of naturally occurring intussusception is known to increase significantly between the ages of 3 and 8 months. Post-licensure studies have reported a fivefold and twofold increase in intussusception in the first week after the first dose and second dose, respectively, of current rotavirus vaccines (RVs). Purpose We carried out a public health risk analysis to model the impact of age at first vaccination in relation to rotavirus vaccination and risk of intussusception in infants. Method We created a static model for a birth cohort followed until 1 year old to estimate the number of excess intussusception hospitalizations which could be caused by three different infant rotavirus vaccination schedules. A relative risk of 5.45 in the first 7 days after the first dose and 1.75 in the first 7 days after the second dose was used in the model. Result We estimated that the risk of intussusception would be the lowest at about 1 in 49,000 if both first and second dose RVs were given at 3 months old. Conclusion Our epidemiological example illustrates the importance of ensuring that the first two doses of RVs are administered in infants

Date: 2016
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DOI: 10.1007/s40264-016-0424-y

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