Effect of Medications for Gastric Acid-Related Symptoms on Total Motile Sperm Count and Concentration: A Case–Control Study in Men of Subfertile Couples from the Netherlands

Nicole A. Huijgen, Hedwig J. Goijen, John M. Twigt, Annemarie G. M. G. J. Mulders, Jan Lindemans, Gert R. Dohle, Joop S. E. Laven and Régine P. M. Steegers-Theunissen ()
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Nicole A. Huijgen: Erasmus MC
Hedwig J. Goijen: Erasmus MC
John M. Twigt: Erasmus MC
Annemarie G. M. G. J. Mulders: Erasmus MC
Jan Lindemans: Erasmus MC
Gert R. Dohle: Erasmus MC
Joop S. E. Laven: Erasmus MC
Régine P. M. Steegers-Theunissen: Erasmus MC

Drug Safety, 2017, vol. 40, issue 3, No 5, 248 pages

Abstract: Abstract Introduction Gastric acid-related symptoms are highly prevalent in the general population (21–40%), and more than 11% of individuals use medication for the treatment of these symptoms. The uptake of micronutrients is dependent on the gastrointestinal potential of hydrogen (pH). Objective We hypothesized that medication affecting gastrointestinal pH reduces the availability of B vitamins, thereby deranging one-carbon metabolism and detrimentally affecting spermatogenesis. Methods This explorative nested case–control study in men of subfertile couples investigated associations between medication used for gastric acid-related symptoms and semen parameters. We included 40 men using medication for gastric acid-related symptoms and 843 men not using medication. Semen analyses were performed between 70 days before and 21 days after the visit. Results The use of medication was associated with a twofold higher risk of a low total motile sperm count [TMSC

Keywords: Sperm Motility; Cobalamin; Sperm Count; Medication User; Sperm Concentration (search for similar items in EconPapers)
Date: 2017
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DOI: 10.1007/s40264-016-0488-8

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