Risks of Opioids in ST-Elevation Myocardial Infarction: A Review

Anne Henrieke Tavenier (), Renicus Suffridus Hermanides, Jan Paul Ottervanger, Peter Gerrit Johannes Horst, Elvin Kedhi and Adriaan W. J. Hof
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Anne Henrieke Tavenier: Isala
Renicus Suffridus Hermanides: Isala
Jan Paul Ottervanger: Isala
Peter Gerrit Johannes Horst: Isala
Elvin Kedhi: Isala
Adriaan W. J. Hof: Maastricht University Medical Center

Drug Safety, 2018, vol. 41, issue 12, No 4, 1303-1308

Abstract: Abstract Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.

Date: 2018
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DOI: 10.1007/s40264-018-0710-y

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