The Uncertainty of the Association Between Proton Pump Inhibitor Use and the Risk of Dementia: Prescription Sequence Symmetry Analysis Using a Korean Healthcare Database Between 2002 and 2013

Sun-Kyeong Park, Yeon-Hee Baek, Nicole Pratt, Lisa Kalisch Ellett and Ju-Young Shin ()
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Sun-Kyeong Park: Sungkyunkwan University
Yeon-Hee Baek: Sungkyunkwan University
Nicole Pratt: University of South Australia
Lisa Kalisch Ellett: University of South Australia
Ju-Young Shin: Sungkyunkwan University

Drug Safety, 2018, vol. 41, issue 6, No 7, 615-624

Abstract: Abstract Introduction Studies have found an association between the use of proton pump inhibitors (PPIs) and dementia, but these findings may have been confounded by selection biases. Objective We used prescription sequence symmetry analysis (PSSA) to estimate the sequence ratio (SR) between PPI use and dementia compared with an active comparator, the use of histamine-2 receptor antagonists (H2RAs). Methods We conducted a PSSA on a nationwide South Korean database between 2002 and 2013. Exposure was defined as new PPI users, and outcome was defined as a new dementia diagnosis (International Statistical Classification of Diseases and Related Health Problems, 10th revision [ICD-10] codes F00-03, F05.1, G30, G31.1, G31.9, G31.82). In this study, we applied the 3-year time window. So the patients who initiated PPIs 3 years before or after their first diagnosis of dementia were included. The pairs with the time window

Date: 2018
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DOI: 10.1007/s40264-018-0638-2

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