Psoriasis After Exposure to Angiotensin-Converting Enzyme Inhibitors: French Pharmacovigilance Data and Review of the Literature

Brahim Azzouz (), Aurore Morel, Lukshe Kanagaratnam, Emmanuelle Herlem and Thierry Trenque
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Brahim Azzouz: Reims University Hospital
Aurore Morel: Reims University Hospital
Lukshe Kanagaratnam: University of Reims Champagne-Ardenne
Emmanuelle Herlem: Reims University Hospital
Thierry Trenque: Reims University Hospital

Drug Safety, 2019, vol. 42, issue 12, No 10, 1507-1513

Abstract: Abstract Introduction Angiotensin-converting enzyme inhibitors (ACEIs) can induce or aggravate psoriasis. This risk is not specified in the Summary of Product Characteristics (SmPC) of some drugs of this class, such as captopril or enalapril. We aimed to investigate the association between psoriasis and ACEI exposure. Methods We analyzed spontaneous reports recorded in the French national Pharmacovigilance Database (FPVD) from 1985 to 31 December 2018. The association between psoriasis and ACEI exposure was assessed using the case/non-case method. We also reviewed literature reports. Results One hundred reports of psoriasis after ACEI exposure were registered in the FPVD. The reporting odds ratio (ROR) was 2.40 (95% CI 1.96–2.95). Time to onset was

Date: 2019
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DOI: 10.1007/s40264-019-00865-8

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