Drug-Induced Anaphylaxis in a Vietnamese Pharmacovigilance Database: Trends and Specific Signals from a Disproportionality Analysis

Khac-Dung Nguyen, Hoang-Anh Nguyen, Dinh-Hoa Vu, Thi Thuy-Linh Le, Hoang-Anh Nguyen, Bich-Viet Dang, Trung-Nguyen Nguyen, Dang-Hoa Nguyen, Thanh-Binh Nguyen, Jean-Louis Montastruc and Haleh Bagheri ()
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Khac-Dung Nguyen: Hanoi University of Pharmacy
Hoang-Anh Nguyen: Hanoi University of Pharmacy
Dinh-Hoa Vu: Hanoi University of Pharmacy
Thi Thuy-Linh Le: Hanoi University of Pharmacy
Hoang-Anh Nguyen: Hanoi University of Pharmacy
Bich-Viet Dang: Hanoi University of Pharmacy
Trung-Nguyen Nguyen: Bach Mai Hospital
Dang-Hoa Nguyen: Hanoi University of Pharmacy
Thanh-Binh Nguyen: Hanoi University of Pharmacy
Jean-Louis Montastruc: Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d’Information sur le Médicament (Midi-Pyrenees Centre for Pharmacovigilance, Pharmacoepidemiology and Drug Information), UMR INSERM 1027
Haleh Bagheri: Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d’Information sur le Médicament (Midi-Pyrenees Centre for Pharmacovigilance, Pharmacoepidemiology and Drug Information), UMR INSERM 1027

Drug Safety, 2019, vol. 42, issue 5, No 9, 682 pages

Abstract: Abstract Introduction Despite the numerous studies investigating drug-induced anaphylaxis (DIA), understanding and quantitative data analysis in developing countries remain limited. The aim of our study is to describe and quantify DIA using the National Pharmacovigilance Database of Vietnam (NPDV). Methods Spontaneous reporting of adverse drug reactions (ADRs) recorded between 2010 and 2016 were retrospectively analysed to identify DIA reports. The trend and characteristics of DIA cases were described. Multivariate disproportionality analysis was used for signal generation. Results Overall, 4873 DIA cases (13.2% of total ADRs) were recorded in the NPDV, 111 of which resulted in death (82% of total ADR-induced deaths) over a 7-year period. There was a remarkable increase in DIA reporting over time (p

Date: 2019
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DOI: 10.1007/s40264-018-0758-8

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